My academic achievements and scholarship fall into two areas: basic research on lung inflammation and fibrosis and interstitial lung disease.  I am credited with the discovery that the extracellular matrix glycosaminoglycan hyaluronan (HA) becomes fragmented during inflammation and functions as a signaling molecule to stimulate inflammatory responses. We have identified a fundamental role for the hyaluronan cell surface receptor CD44 in removing HA from the inflamed lung. We have defined the genes that are induced by HA fragments in macrophages and most recently have shown that these endogenous matrix degradation products can initiate innate immune responses through Toll-like receptors. We have shown that HA fragments accumulate in the blood of patients with acute lung injury.


PhD Classical Art and Archaeology, University of Michigan (2014) Graduate Teaching Certificate, University of Michigan (2012) Graduate Certificate in Greek and Roman History, University of Michigan (2015) MA Classics – Art and Archaeology, University of Colorado (2007) MA Classics (Hons.), University of St. Andrews (2005)

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    Smith, J., Mierscheid, J. M., Buelow, V.: Stone louse in pleistocene. Submitted to: Medical Geology. (publisher’s acknowledgement of receipt attached)

    John Smith

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