This essay focuses on Patricia Churchland contribution to this interdisciplinary approach towards gaining a holistic understanding of our human nature and realities surrounding us, with specific reference to the perceived framework needed for the development of a unified theory of the mind-brain. A critical engagement with Churchland’s ideas seems to shows that a serious progress could be attained by contemporary philosophers in their engagement with longstanding questions concerning the mind, will, soul or consciousness, and intellect – ideas upon which discourse in metaphysics, epistemology, and ethics built their postulations and theories.