Age-Related Changes in Morphometric Parameters of Hippocampal Neurons in Humans

Age-related changes in the hippocampus (HPO) lead to derangements of all types of memory and changes in emotional reactions. The aim of the present work was to study morphometric measures of neurons in the human HPO during aging. Specimens were obtained at autopsy of 43 people of both genders, aged 21–92 years, divided into four age groups. Specimens were stained with cresyl violet to detect neurons. Neurons were counted per unit area in the pes hippocampi in sections of intrinsic hippocampal fields CA1 and CA3 and the dentate gyrus, with measurement of neuron body profile field areas. Aging was found to be associated with heterochronous loss of nerve cells in the human HPO, this process occurring at different intensities in the midpart and the pes. The extent of age-related death of nerve cells in the human HPO increases in the direction dentate gyrus ⟶ field CA3 ⟶ field CA1. Most parts of the HPO showed compensatory increases in neuron profile field areas from 36 to 74 years, followed by a decrease in subjects more than 75 years old.

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