• Novel Pharmacological Strategies for the Management of Insomnia

    Author(s):
    Alberto Kousuke de la Herran-Arita, Hector Ramses Lopez-Lazcano, Roberto Miranda-Maciel, Deldhy Nicolas Moya-Sánchez (see profile)
    Date:
    2017
    Subject(s):
    Insomnia, Orexins, Benzodiazepines, Histamine, Sleep disorders
    Item Type:
    Article
    Tag(s):
    insomnia, orexin, Histamine, Sleep-Wake Regulation, Hyperarousal
    Permanent URL:
    https://doi.org/10.17613/8fpz-8512
    Abstract:
    Insomnia is a common sleep disorder depicted as a difficulty in initiating or maintaining sleep, or non-restorative sleep with impairment of day time functioning, such as irritability or fatigue during wakefulness. The etiology and pathophysiology of insomnia is complex, it involves genetic, environmental, behavioral, and physiological factors that culminate in hyperarousal, a state of increased psychological and physiological stress. This condition results in a disarray of the sleep-wake cycle, and the development of subsequent collateral symptoms such as fatigue, attention deficit, and mood wavering, among many others. Current pharmacological treatment for insomnia is in the form of benzodiazepine (BZD) receptor agonist drugs (GABA-A receptor). Nonetheless, the administration of these molecules is not idyllic, due to their safety profile and inadequate efficacy.The recent progress in elucidating the processes that orchestrate sleep/wake regulation will improve the way that insomnia is approached. Current studies have emphasized new targets for drug discovery. In this Review, we will summarize the research on sleep–wake cycle modulators that may be of relevance for treating insomnia.
    Notes:
    https://www.gavinpublishers.com/article/view/novel-pharmacological-strategies-for-the-management-of-insomnia
    Metadata:
    xml
    Published as:
    Journal article     Show details
    Pub. DOI:
    https://www.gavinpublishers.com/article/view/novel-pharmacological-strategies-for-the-management-of-insomnia
    Publisher:
    J Neurol Exp Neural Sci
    Pub. Date:
    2017
    Journal:
    Journal of Neurology and Experimental Neural Science
    Volume:
    1
    Issue:
    2
    Page Range:
    1 - 6
    ISSN:
    2577-1442
    Status:
    Published
    Last Updated:
    1 week ago
    License:
    Attribution
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